The Wyoming Valley Conference Division 2 girls basketball schedule includes 12 games for each of the 7 teams – Hanover Area, Holy Redeemer, Lake-Lehman, MMI Prep, Nanticoke, Wyoming Area and Wyoming Seminary.
Each division team plays home-and-home against all of its division rivals.
| Date | Visitor | Home |
| Dec. 21 | Nanticoke | Wyoming Seminary |
| Dec. 21 | Wyoming Area | MMI Prep |
| Dec. 21 | Hanover Area | Holy Redeemer |
| Jan. 3 | Holy Redeemer | Lake-Lehman |
| Jan. 3 | MMI Prep | Nanticoke |
| Jan. 3 | Wyoming Seminary | Hanover Area |
| Jan. 5 | Holy Redeemer | MMI Prep |
| Jan. 5 | Lake-Lehman | Wyoming Area |
| Jan. 5 | Hanover Area | Nanticoke |
| Jan. 9 | Nanticoke | Lake-Lehman |
| Jan. 9 | Wyoming Area | Holy Redeemer |
| Jan. 9 | MMI Prep | Wyoming Seminary |
| Jan. 12 | Hanover Area | MMI Prep |
| Jan. 12 | Nanticoke | Wyoming Area |
| Jan. 12 | Lake-Lehman | Wyoming Seminary |
| Jan. 16 | Wyoming Seminary | Holy Redeemer |
| Jan. 16 | Wyoming Area | Hanover Area |
| Jan. 16 | MMI Prep | Lake-Lehman |
| Jan. 18 | Wyoming Seminary | Wyoming Area |
| Jan. 18 | Holy Redeemer | Nanticoke |
| Jan. 18 | Lake-Lehman | Hanover Area |
| Jan. 20 | Wyoming Seminary | Nanticoke |
| Jan. 20 | MMI Prep | Wyoming Area |
| Jan. 20 | Lake-Lehman | Hanover Area |
| Jan. 23 | Lake-Lehman | Holy Redeemer |
| Jan. 23 | Nanticoke | MMI Prep |
| Jan. 23 | Hanover Area | Wyoming Seminary |
| Jan. 26 | MMI Prep | Holy Redeemer |
| Jan. 26 | Wyoming Area | Lake-Lehman |
| Jan. 30 | Holy Redeemer | Wyoming Area |
| Jan. 30 | Wyoming Seminary | MMI Prep |
| Feb. 2 | MMI Prep | Hanover Area |
| Feb. 2 | Wyoming Area | Nanticoke |
| Feb. 2 | Wyoming Seminary | Lake-Lehman |
| Feb. 6 | Holy Redeemer. | Wyoming Seminary |
| Feb. 6 | Hanover Area | Wyoming Area |
| Feb. 6 | Lake-Lehman | MMI Prep |
| Feb. 8 | Wyoming Area | Wyoming Seminary |
| Feb. 8 | Nanticoke | Holy Redeemer |
| Feb. 8 | Hanover Area | Lake-Lehman |
